Our New Study Highlights the Impact of the Paris System for Reporting Urine Cytology on Diagnostic Performance

Jun 28
Our recent systematic review and meta-analysis published at the Journal of Cytopathology, evaluated the effects of the Paris System for Reporting Urine Cytology (TPS) on improving diagnostic performance and clinical utility. Urine cytology, a noninvasive tool used for screening genitourinary tract neoplasms, has faced challenges due to the lack of standardized terminology and clear morphological criteria.

The study, which searched six electronic databases, included 64 studies comprising a total of 99,796 urine cytology samples from January 2004 to December 2022. Researchers compared the diagnostic accuracy between TPS and non-TPS cohorts to assess the impact of TPS implementation.

Key findings include:
  • The adoption of TPS led to an increased frequency of negative for high-grade urothelial carcinoma (NHGUC) diagnoses and a reduction in atypical urothelial cells (AUC) diagnoses.
  • The ratio of atypical to high-grade malignancy (AUC/HGM) significantly decreased in the TPS cohort, indicating more precise diagnoses.
  • The frequency of low-grade urothelial neoplasms (LGUN) diagnosed as AUC also significantly decreased in the TPS cohort compared to non-TPS cohorts.
  • The study found that TPS improved the clinical utility of suspicious for high-grade urothelial carcinoma (SHGUC) and HGM diagnoses in detecting high-grade lesions.
Despite these improvements, the study noted that an NHGUC diagnosis still does not reliably rule out the presence of a high-grade lesion, indicating a need for continued refinement in urine cytology reporting.

The findings underscore the importance of standardized reporting systems like TPS in enhancing diagnostic accuracy and clinical outcomes for patients under surveillance for genitourinary malignancies.

We use cookies to provide you with an optimal experience and relevant communication. Learn more or accept individual cookies.

Necessary

Necessary cookies (First Party Cookies) are sometimes called "strictly necessary" as without them we cannot provide the functionality that you need to use this website. For example, essential cookies help remember your preferences as you navigate through the online school.

Functional

Functional cookies enable this website to provide enhanced functionality and personalization, by remembering information you have entered and choices you make. These preferences are remembered through the use of persistent cookies, so that you will not have to set them again the next time you visit the website.

Analytics

Analytics cookies track information about visits on our website so that we can measure and improve its performance, as well as optimize our course content. These cookies help us analyze user behavior by tracking the number of visits, how visitors use the website, which site or page they come from and how long they are staying for.

Marketing

Marketing cookies are used to deliver advertising material relevant to you and your interests. They are also used to limit the number of times you see an advertisement, resulting to more targeted advertising, as well as help us measure the effectiveness of our campaigns. They are usually placed by advertising networks we collaborate with, with our permission.